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Isolated plagiocephaly

1 OMIM reference -
2 associated genes
11 signs/symptoms

COMMON GENES: 1
COMMON SIGNS: 5

Thanatophoric dysplasia type 2

2 OMIM references -
1 associated gene
36 signs/symptoms

Isolated plagiocephaly

Thanatophoric dysplasia type 2

FGFR3	(UniProt - OMIM)		FGFR3	(UniProt - OMIM)
TCF12	(UniProt - OMIM)


COMMON GENES	FGFR3

Citations in the biomedical literature:

Isolated plagiocephaly		Thanatophoric dysplasia type 2
	Synonym(s): - Non-syndromic unicoronal synostosis - Synostotic plagiocephaly		Synonym(s): - Cloverleaf skull - micromelic bone dysplasia - TD2 - Thanatophoric dwarfism - cloverleaf skull - Thanatophoric dwarfism type 2

	Classification (Orphanet): - Rare bone disease - Rare developmental defect during embryogenesis - Rare eye disease - Rare genetic disease		Classification (Orphanet): - Rare bone disease - Rare developmental defect during embryogenesis - Rare genetic disease

	Classification (ICD10): - Congenital malformations, deformations and chromosomal abnormalities -		Classification (ICD10): - Congenital malformations, deformations and chromosomal abnormalities -

	Epidemiological data: Class of prevalence: 1-5 / 10 000 Average age onset: neonatal/infancy Average age of death: normal Type of inheritance: autosomal dominant		Epidemiological data: Class of prevalence: unknown Average age onset: neonatal/infancy Average age of death: before age 5 Type of inheritance: autosomal dominant

	External references: 1 OMIM reference - No MeSH references		External references: 2 OMIM references - No MeSH references


COMMON SIGNS	- Autosomal dominant inheritance - Frontal bossing / prominent forehead - Hearing loss / hypoacusia / deafness - Intellectual deficit / mental / psychomotor retardation / learning disability - Macrocephaly / macrocrania / megalocephaly / megacephaly

Isolated plagiocephaly		Thanatophoric dysplasia type 2
	Very frequent - Facial structural asymmetry / facial hemiatrophy / facial hemihypertrophy - Plagiocephaly Frequent - Abnormal eye movements / oculomotor disorder - Abnormal visual field / hemianopsia / hemianopia / scotoma / visual peripheral rim - Strabismus / squint Occasional - Mid-facial hypoplasia / short / small midface		Very frequent - Cloverleaf skull - Depressed nasal bridge - Dysostosis / chondrodysplasia / osteodysplasia / osteochondrosis / skeletal dysplasia - Flat face - Hypoplastic lungs / pulmonary hypoplasia / agenesis - Hypotonia - Loose skin / skin relaxation / excess skin / creases - Metaphyseal anomaly - Narrow rib cage / thorax - Platyspondyly - Respiratory distress / dyspnea / respiratory failure / lung volume reduction - Rhizomelic micromelia - Short hand / brachydactyly - Short rib cage / thorax - Short stature / dwarfism / nanism - Stillbirth / neonatal death Frequent - Dilated cerebral ventricles without hydrocephaly - Increased nuchal translucency - Kyphosis - Polyhydramnios - Proptosis / exophthalmos - Seizures / epilepsy / absences / spasms / status epilepticus Occasional - Acanthosis nigricans - Agyria / micro / pachy / macrogyria / lissencephaly / gyration / neuronal migration defect - Atrial septal defect / interauricular communication - Encephalocele / exencephaly - Holoprosencephaly / arhinencephaly / unique lateral ventricle - Hydrocephaly - Patent ductus arteriosus - Renal / kidney anomalies - Restricted joint mobility / joint stiffness / ankylosis